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The approximate half-life of Pristiq (Desvenlafaxine) is 11 hours. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most common AEs seen in both sexes and all ethnicities Op · 2 yr. Some of the most common side effects of desvenlafaxine include: excess sweating, dizziness, agitation, drowsiness, constipation, loss of appetite, dry mouth, nausea, weight loss, blurred vision, and decreased sex drive Pristiq Withdrawal Duration. Pristiq is indicated for the treatment of adults with major depressive disorder (MDD) [see Clinical Studies (14)].