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On a chemical level, Buspirone is unlike Xanax and other benzodiazepines, and it affects the brain differently. They are both for treating anxiety and the mechanisms in which they do so are similar, however , again they are not one in the same. May also be prescribed off label for more Prescription only. Prescribed more Prescription only. Buspirone and Xanax ( alprazolam) are medications used to treat anxiety. It is classed with other anxiolytics, or anti-anxiety medications, but it is not chemically related to benzodiazepines, sedatives, or any other anti-anxiety medications Generic Xanax Availability. Buspirone is available as a generic drug Alprazolam Intensol, Xanax, Xanax XR BuSpar Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. BuSpar (buspirone) Xanax (alprazolam) Prescription only BuSpar is used for the treatment of anxiety and is less likely than most other anti-anxiety medicines to cause sedation; however, its effects on individual patients may be unpredictable. Buspirone Xanax (alprazolam) Prescription only Buspirone may be used for the treatment of anxiety and is less likely to cause sedation than other anti-anxiety drugs. Xanax is in the benzodiazepine class of drugs, while buspirone is not chemically related to benzodiazepines and works differently than other anxiolytics. Xanax is in the benzodiazepines class of drugs, whereas Buspar is not. In both groups, six out of 12 patients successfully completed withdrawal. Twenty four long-term benzodiazepine users were allocated randomly to treatment with either buspirone (mean dose 25 mg/day) or placebo, prior to tapering off the benzodiazepine over 6 weeks. Xanax is a brand name of alprazolam, approved by the FDA in the following formulation(s): XANAX (alprazolam - tablet;oral) Manufacturer: UPJOHN Approved Prior to Jan 1, 1982 Strength(s): 0. Buspirone also has a lower risk of physical dependence or addiction and causes less sedation than benzodiazepines.. Prescribed for Anxiety, Panic Disorder. Right now, one of the most commonly prescribed drugs for anxiety — buspirone, which is still known by its discontinued brand name BuSpar — is in short supply. 5MG , 1MG ; Manufacturer: UPJOHN. Buspirone and Xanax are both prescription medications used to treat anxiety, but the drugs have several key differences. Buspar is not the same as xanax and the commenters stating that they are the same drug class are also wrong. The brand name of buspirone called BuSpar is discontinued in the U. However, buspirone-treated patients ….